SubjectWell Unveils New Science-Driven Framework to Transform Protocol Design, Recruitment, Engagement, and Retention

SubjectWell, the largest global patient experience platform for clinical trials, announced a major advancement in how science guides every stage of the clinical trial recruitment and engagement lifecycle. By integrating Patient Burden Index (PBI), Site Burden Index (SBI), and standards-of-care data into its modeling and execution, SubjectWell is redefining how sponsors design protocols, forecast feasibility, drive enrollment, and sustain long-term patient participation.

SubjectWell’s new patient-centric and science-centered approach provides trial sponsors with unprecedented visibility into the true operational impact of a study—on participants, investigators, and recruitment teams—before enrollment begins. These insights support more realistic timelines, more predictable performance, and higher-quality experiences for patients and sites.

“Clinical trial success hinges on the intersection of great science and real-world patient understanding,” said Fred Martin, CEO of SubjectWell. “We are pioneering the next era of evidence-based recruitment by integrating burden indices and standard-of-care benchmarks directly into the core planning processes: protocol evaluation, recruitment strategy, engagement design, and retention. This ensures sponsors have the data needed to accurately forecast and manage participant enrollment and long-term adherence.”

Integrating Science Across the Trial Lifecycle

Protocol Review and Feasibility Forecasting
SubjectWell now evaluates protocols using PBI and SBI to understand how visit schedules, procedures, geography, and eligibility criteria affect real-world patient and site participation. Combined with standards-of-care insights, these models highlight feasibility risks early—before they become enrollment barriers.

Recruitment Modeling and Media Strategy
Historical performance data is merged with burden indices to create science-grounded feasibility predictions. By quantifying how protocol difficulty impacts conversion rates, SubjectWell builds recruitment strategies that precisely match the study’s operational complexity.

Patient Engagement and Experience Design
Understanding burden allows SubjectWell to tailor creative, messaging, and outreach tactics to patient motivations and concerns. This ensures materials are empathetic, accurate, and aligned to how real patients navigate symptoms, diagnosis pathways, and treatment decisions.

Retention and Site Operations Support
Standards-of-care benchmarks help SubjectWell anticipate where drop-off may occur during screening or participation. This informs supportive engagement touchpoints and site enablement strategies designed to maintain patient commitment and reduce operational friction.

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A Breakthrough for Sponsors and Sites

The integration of burden indices and standards-of-care data equips sponsors with:

• More accurate feasibility assessments
• Predictable funnel modeling and budget planning
• Recruitment strategies matched to protocol complexity
• Improved patient and site experience
• Higher retention and more consistent enrollment across sites

For sites, this approach reduces administrative load, improves patient preparedness, and aligns trial expectations with local care realities.

Setting a New Industry Standard
“Burden is measurable—and when you measure it, you can design smarter,” added Dr. Matthias Roos, Director of Scientific Affairs of SubjectWell. “We’re proud to lead the industry toward a more scientific, transparent, and human-centered model of clinical trial recruitment.”

SubjectWell’s science-driven framework is now available for all new sponsor engagements globally.